Anti - Aging

TERT, Follistatin, and Klotho gene therapies target different aspects of aging but can work synergistically to enhance longevity, improve tissue function, and prevent age-related decline. Here’s how each plays a role in anti-aging:

1. TERT (Telomerase Reverse Transcriptase) – Extending Cellular Lifespan

Function: TERT is a key component of telomerase, the enzyme that lengthens telomeres, which shorten with each cell division. Short telomeres are associated with aging, cellular senescence, and increased disease risk.

Anti-Aging Benefits:

Extends the lifespan of stem cells and somatic cells, delaying age-related decline.

Improves organ regeneration and tissue repair.

Enhances mitochondrial function, reducing oxidative stress and inflammation.

Potential Uses: Preventing or reversing age-related diseases, improving skin health, and maintaining cognitive function.

2. Follistatin – Muscle Growth, Strength, and Metabolic Health

Function: Follistatin inhibits myostatin, which naturally limits muscle growth, and also modulates activin signaling, impacting inflammation and tissue repair.

Anti-Aging Benefits:

Increases muscle mass & strength, preventing sarcopenia (age-related muscle loss).

Enhances metabolic health by reducing white fat and improving insulin sensitivity.

Promotes tissue repair, reducing frailty and maintaining mobility.

Potential Uses: Strength maintenance in aging, recovery from injuries, and metabolic disease prevention.

3. Klotho – Cognitive Function, Kidney Health, and Longevity

Function: Klotho is a longevity-associated protein that regulates calcium and phosphate metabolism, protects the kidneys, and enhances cognitive function by improving synaptic plasticity.

Anti-Aging Benefits:

Protects brain function, reducing risk of neurodegenerative diseases like Alzheimer’s.

Enhances kidney function and reduces age-related kidney decline.

Acts as an anti-inflammatory and antioxidant, reducing overall aging damage.

Potential Uses: Preventing cognitive decline, improving lifespan, and maintaining overall systemic health.

How They Work Together

TERT keeps cells young by preventing telomere shortening, reducing senescence, and maintaining regenerative capacity.

Follistatin preserves strength, function, and metabolic health, preventing the physical decline of aging.

Klotho protects the brain, kidneys, and metabolism, reducing inflammation and oxidative damage.

Together, these three gene therapies could extend both lifespan and healthspan, helping individuals maintain a youthful, functional state for longer.

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